Background. Renal vasoconstriction, oxidative stress, endothelial dysfunction, and apoptosis are the major causes of contrastinduced\nnephropathy (CIN). The aim of this study was to evaluate the protective effects of enalapril maleate and folic acid tablets\nonCIN in diabetic rats. Methods. Thirty-two Sprague-Dawley rats were divided into four groups: CIN (C), CIN + enalapril maleate\n(CE), CIN + folic acid (CF), and CIN + enalapril maleate and folic acid tablets (CEF). CE, CF, and CEF rats were treated orally\nwith enalapril maleate, folic acid, or enalapril maleate and folic acid tablets, respectively, for 5 days. CIN was induced in all groups\nfollowed by analyzed biochemical parameters, oxidative stress markers, endothelial dysfunction parameters, renal histopathology,\nand TUNEL staining. Results. Serum creatinine, blood urea nitrogen, and malondialdehyde levels were lower in the CEF group\nthan in the C group. Homocysteine, superoxide dismutase, glutathione peroxidase, and nitric oxide levels were higher in the CEF\ngroup than in the C group. Histopathology scores and percentage of apoptotic kidney cells in the CEF group were significantly\ndecreased compared with those in the C group. Conclusions.These results suggest that enalapril maleate and folic acid tablets have\na protective effect against CIN in diabetic rats.
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